The Jubilee Mission Hospital, a Christian Minority Institution, was established in the year 1952. Subsequently Medical College has been established and made functional in the year 2003. The Medical College has MCI recognition for 100 MBBS seats, 16 Postgraduate Programme (total 35 seats) and 2 Super specialty (DM) courses (total 3 seats). H.G. Mar Andrews Thazhath, Archbishop of Thrissur is the Patron and Chairman of the Jubilee Mission Medical College and Research Institute.

The first batch of Medical students were admitted to the Jubilee Mission Medical College & Research Institute, Thrissur and the classes commenced on 22/09/2003 after fulfilling the requirements of Medical Council of India. This college was affiliated to the University of Calicut and is housed at the Heart of the city of Thrissur.

Thirteen batches of Medical students have been admitted in the medical college from the year 2003 onwards and seventh batch (last batch of Calicut University) have already graduated. The students of 2010 admission onwards are affiliated to the Kerala University of Health Sciences, Mulangunnathukavu, Thrissur.