Sir Sayajirao General Hospital (S.S.G.H) Vadodara was started in 1865 as the 56 bedded Countess of Dufferin Hospital. This was then taken over by the Government of Gujarat in 1907 and renamed the S.S.G Hospital after the erstwhile ruler of Vadodara, Maharaja Sayajirao II. S.S.G Hospital is designed in the Indo-Saracen style. It is the largest referral hospital in Central Gujarat.
It forms the teaching hospital component of Medical College Baroda. It also houses the Government College of Physiotherapy and Government Nursing College. It caters to the primary, secondary and tertiary health care needs of the people of central Gujarat and adjoining states of Madhya Pradesh and Rajasthan. It also participates in various community outreach and national health programs.

It has 1250 teaching beds across several clinical specialties and subspecialties, with an annual average outdoor attendance of about 9 Lakh patients, an average annual indoor admission of 67,000 patients and a bed occupancy rate of 90%.